Artículos científicos sobre psicosis temprana

Esta sección reúne una amplia selección de artículos científicos en los que participan investigadores de Imhay y que abordan distintas dimensiones de la psicosis en etapas tempranas.

En conjunto, estos trabajos ofrecen evidencia actualizada sobre la prevalencia de experiencias psicóticas, sus factores asociados, herramientas de evaluación clínica y cognitiva, así como intervenciones tempranas. Además, incluyen reflexiones éticas y aproximaciones innovadoras que contribuyen al entendimiento y tratamiento oportuno de este tipo de experiencias en adolescentes y jóvenes.

González-Medina, G. A., Corral, S. A., Castillo-Passi, R. I., Irarrazaval, M., Maturana-Hurtado, A. J., & Gaspar, P. A. (2024). Lifetime prevalence of psychotic-like experiences and associated factors in Chile. Social Psychiatry and Psychiatric Epidemiologyhttps://doi.org/10.1007/s00127-024-02741-y

Anagnostopoulou, N., Papachristou, E. (Steven), Galitzer, H., Alba, A., Gaete, J., Dima, D., Rogdaki, M., Salazar de Pablo, G., & Kyriakopoulos, M. (2024). Psychotic symptoms with and without a primary psychotic disorder in children requiring inpatient mental health admission. European psychiatry: the journal of the Association of European Psychiatrists, 1-31. https://doi.org/10.1192/j.eurpsy.2024.23

Wigman, J. T. W., Ching, A. E., Chung, Y., Eichi, H. R., Lane, E., Langholm, C., Vaidyam, A., Byun, A. J. S., Haidar, A., Hartmann, J., Nunez, A., Dwyer, D., Nasarudin, A. A., Borders, O., Scott, I., Tamayo, Z., Matneja, P., Cho, K. I., Addington, J., Alameda, L. K., … Gaspar, P. A., … Torous, J. (2025). Digital health technologies in the accelerating medicines Partnership® Schizophrenia Program. Schizophrenia (Heidelberg, Germany)11(1), 83. https://doi.org/10.1038/s41537-025-00599-w

Mathalon, D. H., Nicholas, S., Roach, B. J., Billah, T., Lavoie, S., Whitford, T., Hamilton, H. K., Addamo, L., Anohkin, A., Bekinschtein, T., Belger, A., Buccilli, K., Cahill, J., Carrión, R. E., Damiani, S., Dzafic, I., Ebdrup, B. H., Izyurov, I., Jarcho, J., Jenni, R., … Mayol-Troncoso, R., … Castillo-Passi, R. I., … Gaspar, P. A., … Light, G. A. (2025). The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures. Schizophrenia (Heidelberg, Germany)11(1), 85. https://doi.org/10.1038/s41537-025-00622-0

Ulloa, J. L.Núñez, D. E.Gaspar, P. A., & Brass, M. (2024). Imitative inhibitory control is associated with psychotic experiences in a sample from the general population. Frontiers in Psychiatry, 15, Article 1470030. https://doi.org/10.3389/fpsyt.2024.1470030

González-Medina, G. A., Corral, S. A., Castillo-Passi, R. I., Irarrazaval, M., Maturana-Hurtado, A. J., & Gaspar, P. A. (2024). Lifetime prevalence of psychotic-like experiences and associated factors in Chile. Social Psychiatry and Psychiatric Epidemiologyhttps://doi.org/10.1007/s00127-024-02741-y

Núñez, D., Rodríguez-Delgado, J., Castillo, R. D., Yupanqui, J., & Kloos, H. (2024). Effect of prior beliefs and cognitive deficits on learning in first-episode schizophrenia patients. Schizophrenia Research: Cognition, 38, 100318. https://doi.org/10.1016/j.scog.2024.100318

Wannan, C., Nelson, B., Addington, J., Allott, K., Anticevic, A., Arango…Gaspar ,P.Castillo-Passi, R.Mayol-Troncoso, R.Turra-Fariña, G...& Whitson, S.(2024). Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis. Schizophrenia Bulletinhttps://doi.org/10.1093/schbul/sbae011

Palominos, C., Figueroa-Barra, A., & Hinzen, W. (2023). Coreference delays in psychotic discourse: Widening the temporal window. Schizophrenia Bulletin. https://doi.org/10.1093/schbul/sbac102

Figueroa-Barra, A., León, M. E., & Gaspar, P. A. (2022). Las anomalías precoces de la continuidad en el discurso constituyen biomarcadores predictivos de psicosis. Rilce Revista de Filología Hispánica, 38(3)https://doi.org/10.15581/008.38.3.1016-49

Langer, Á. I., Wardenaar, K., Wigman, J., Ulloa, J. L., & Núñez, D. E., (2022). A Latent Profile Analysis of psychotic experiences, non-psychotic symptoms, suicidal ideation and underlying mechanisms in a sample of adolescents from the general population. Frontiers in Psychiatry, 13https://doi.org/10.3389/fpsyt.2022.926556

Figueroa-Barra, A., Del Águila, D., Cerda, M., Gaspar, P. A., Terissi, L. D., Durán, M., & Valderrama, C. (2022). Automatic language analysis identifies and predicts schizophrenia in first-episode of psychosis. Schizophrenia, 8(53). https://doi.org/10.1038/s41537-022-00259-3

Martínez, A., Tobe, R. H., Gaspar, P. A., Malinsky, D., Dias, E. C., Sehatpour, P., Lakatos, P., Patel, G. H., Bermudez, D. H., Silipo, G., & Javitt, D. C. (2022). Disease-specific contribution of pulvinar dysfunction to impaired emotion recognition in schizophrenia. Frontiers in Behavioral Neuroscience, 15. https://doi.org/10.3389/fnbeh.2021.787383

Olivares, I., & Figueroa, A. (2021). Análisis de alteraciones del discurso en estados mentales de alto riesgo de psicosis (EMAR): una revisión sistemática. Revista Chilena de Neuro-psiquiatría, 59(4), 343-360.  http://dx.doi.org/10.4067/S0717-92272021000400343

Czepielewski, L. S., Alliende, L. M., Castañeda, C. P., Castro, M., Guinjoan, S. M., Massuda, R., Berberian, A. A., Fonseca, A. O., Gadelha, A., Bressan, R., Crivelaro, M., Louza, M., Undurraga, J., González-Valderrama, A., Nachar, R., Nieto, R. R., Montes, C., Silva, H., Langer, Á. I., Schmidt, C., Mayol-Troncoso, R., Díaz-Zuluaga, A. M., Valencia-Echeverry, J., López-Jaramillo, C., Solís-Vivanco, R., Reyes Madrigal, F., de la Fuente-Sandoval, C., Crossley, N. A., & Gama, C. S. (2021). Effects of socioeconomic status in cognition of people with schizophrenia: results from a Latin American collaboration network with 1175 subjects. Psychological Medicine, 1-12. https://doi.org/10.1017/S0033291721002403

Nieto, R. R., Carrasco, A., Corral, S., Castillo, R.Gaspar, P. A., Bustamante, M. L., & Silva, H. (2021). BDNF as a biomarker of cognition in schizophrenia/psychosis: an updated review. Frontiers in Psychiatry, 12https://doi.org/10.3389/fpsyt.2021.662407

Núñez, D.Ordóñez-Carrasco, J. L.Fuentes, R., & Langer, Á. I. (2021). Experiential avoidance mediates the association between paranoid ideation and depressive symptoms in a sample from the general population. Journal of Psychiatric Research, 139, 120-124.  https://doi.org/10.1016/j.jpsychires.2021.05.028

Galitzer, H., Anagnostopoulou, N., Alba, A., Gaete, J., Dima, D., & Kyriakopoulos, M. (2020). Functional outcomes and patient satisfaction following inpatient treatment for childhood‐onset schizophrenia spectrum disorders vs non‐psychotic disorders in children in the United Kingdom. Early Intervention in Psychiatry. https://doi.org/10.1111/eip.12973

Gaspar, P. A.Castillo, R. I., Maturana, A., Villar, M. J., Ulloa, K., González, G., Ibaceta, O., Ortiz, A., Corral, S., Mayol, R., De Angel, V., Aburto, M. B.Martínez, A., Corcoran, C. M., & Silva, H. (2018). Early psychosis detection program in Chile: A first step for the South American challenge in psychosis research. Early Intervention in Psychiatry, 13(2), 328-334. https://doi.org/10.1111/eip.12766

Mayol-Troncoso, R., Gaspar, P. A., Verdugo, R., Mariman, J. J., & Maldonado, P. E. (2024). Fixational eye movements and their associated evoked potentials during natural vision are altered in schizophrenia. Schizophrenia Research: Cognition, 38, 100324. https://doi.org/10.1016/j.scog.2024.100324

Addington, J., Liu, L., Braun, A., Auther, A., Calkins, M. E., Cornblatt, B. A., Corcoran, C. M., Fusar-Poli, P., Kerr, M. J., Mourgues-Codern, C. V., Nunez, A. R., Oliver, D., Strauss, G. P., Walsh, B. C., Alameda, L. K., Arango, C., Breitborde, N. J. K., Broome, M. R., Cadenhead, K. S., Carrion, R. E., … Gaspar, P. A., … Yung, A. R. (2025). Sample ascertainment and clinical outcome measures in the Accelerating Medicines Partnership® Schizophrenia Program. Schizophrenia (Heidelberg, Germany)11(1), 54. https://doi.org/10.1038/s41537-025-00556-7

Allott, K., Yassin, W., Alameda, L., Billah, T., Borders, O., Buccilli, K., Carrión, R. E., Castillo-Passi, R. I., Cho, K. I. K., Chin, K., Coleman, M. J., Colton, B. L., Corral, S., Dwyer, D., Gundersen, K. B., Gur, R. C., Hoftman, G. D., Jacobs, G. R., Kelly, S., Lewandowski, K. E., … Gaspar, P. A., … Stone, W. S. (2025). Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample. Schizophrenia (Heidelberg, Germany)11(1), 49. https://doi.org/10.1038/s41537-025-00578-1

Villacura-Herrera, C., Pérez, J., Jones, P. B., & Núñez, D. (2024). Internal Consistency and Temporal Stability of the Community Assessment of Psychic Experiences (CAPE): A Reliability Generalization Meta-Analysis. Psychiatry Research, 115988. https://doi.org/10.1016/j.psychres.2024.115988

Corral, S., Gaspar, P. A.Castillo-Passi, R. I.Mayol Troncoso, R., Mundt, A. P., Ignatyev, Y., Nieto, R. R., Figueroa-Muñoz, A. (2024). Montreal Cognitive Assessment (MoCA) as a screening tool for cognitive impairment in early stages of psychosis. Schizophrenia Research: Cognition, 36https://doi.org/10.1016/j.scog.2024.100302

Woods, S. W., Parker, S., Kerr, M. J., Walsh, B. C., Wijtenburg, S. A., Prunier, N., …, Gaspar, P.,…, & Accelerating Medicines Partnership Schizophrenia. (2023). Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS. Early Intervention in Psychiatry, 1-18. https://doi.org/10.1101/2023.04.29.23289226

Rivera, G., Fuentes-Ferrada, R., Krogh, E., & Langer, Á. I. (2023). Mindfulness and compassion as a path to recovery and personal discovery: a first-episode schizophrenia case study . En J. A. Díaz-Garrido, R. Zúñiga, H. Laffite, & E. Morris (eds) Psychological Interventions for Psychosis (pp. 539-557). Springerhttps://doi.org/10.1007/978-3-031-27003-1_25

Rivera, G., Fuentes-Ferrada, R., Krogh, E., & Langer, A. I. (2022). Mindfulness y compasión como vía de recuperación y encuentro personal: un estudio de caso en un primer episodio de esquizofrenia. En J. Díaz, R. Zúñiga, H. Laffite, & E. Morris (Coords.) Modelos de cambio. Casos clínicos en psicosis. Pirámide.

Undurraga, J., Gaspar, P., Nachar, R., Díaz, C., Rivera, G., & Noto, C. (2021). Intervención temprana en psicosis, una perspectiva clínica. Revista Latinoamericana de Psiquiatría, 20(2), 22-27. https://www.webapal.org/assets/files/Revista-ApalEdicin2ao2021.pdf

Núñez, D., Godoy, M. I., Gaete, J.Faúndez, M. J.Campos, S., Fresno, A., & Spencer, R. (2021). The Community Assessment of Psychic Experiences-Positive scale (CAPE-P15) accurately classifies and differentiates psychotic experience levels in adolescents from the general population. PLoS ONE, 16(8). https://doi.org/10.1371/journal.pone.0256686

Langer, Á. I., Schmidt, C., Vergara, R., Mayol-Troncoso, R., Lecaros, J., Krogh, E., Vergara., C., Díaz, M., Rivera, G., Aguirre-Baez, R., & Gaspar, P. A. (2020). Examining the effect of a mindfulness based program for the improvement of cognitive function in an early stage of schizophrenia. A random controlled trial. Schizophrenia Research, 223, 370-372. https://doi.org/10.1016/j.schres.2020.07.012

López-Silva, P., & Méndez, E. (2024). Los límites del yo: Hacia una clarificación de la relación entre delirios de inserción de pensamiento y el principio de inmunidad al error a través de la mala identificación. Crítica. Revista Hispanoamericana de Filosofía, 56(167), Article 167. https://doi.org/10.22201/iifs.18704905e.2024.1537

Méndez, E., Figueroa-Barra, A., Martínez, C., & Durán, E. (2024). Exploring stigma towards people with schizophrenia in mass media and their private discourses. Revista Colombiana de Psiquiatría. https://doi.org/10.1016/j.rcp.2022.08.003